Prediction Colts vs. Cardinals, Odds, Anti-Against and Over/Under for NFL Week 16

NFL fans are getting a great present on Christmas Day as the Indianapolis Colts head to State Farm Stadium to play the Arizona Cardinals.

The Cardinals are experiencing one of their worst losses of the season, beaten by the miserably bad Detroit Lions by a 13.5-point favorite. It was their second straight loss and leaves them with a 10-4 record as they chase the lead in the NFC West.

The Colts, on the other hand, are on a fine two-match winning streak and have won five of their last six. Once again, the team led to victory by Jonathan Taylor, who led the league in pitches and touches. He will be tested by a good defense of the Cardinals in need of a redemption game after the Lions fail.

Here are the odds for this Week 16 head-to-head, courtesy of WynnBET Sportsbook.


Cash flow:


Despite the Cardinals’ solid defense, Jonathan Taylor has proven he can run on any team. He doesn’t lead the NFL in rushing by accident. I know a lot of people are calling for the Cardinals to recover and get a much-needed victory here, but I’m not quick to dismiss the Colonels. The Cardinals are just 3-8 ATS at State Farm Stadium, meaning they’re still overrated at home. As an at-home favorite, they’ve only been twice out of six tries.

The loss of DeAndre Hopkins has kept Kyler Murray out of the No 1 game and that showed last week. I think they continued to struggle, unable to contain Taylor, and upset for the third week in a row.

Pick: Indianapolis Colts +105 to win Prediction Colts vs. Cardinals, Odds, Anti-Against and Over/Under for NFL Week 16

John Verrall

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