The bosses in Elden Ring are extremely tough. They are meant to challenge you and force you to learn their movesets in order to defeat them properly. You might be able to take a few hits, but you can’t take all of them. You need every advantage you can have over them. A good question is whether or not a boss can be poisoned in Elden Ring. Here’s what you need to know about poisoning bosses in Elden Ring.
We can confirm that it is possible. There’s a good chance that most of the bosses you encounter may be poisoned. However, it varies from each other. Some bosses may be resistant to the effect or completely immune to poison, meaning your poison-based weapon is better used at another time. The same goes for almost every other one you can use in the game. For example, the Crystalian bosses you may encounter in some dungeons are extremely resistant to slashing or thrusting weapons, but they are weak to blunt and slamming weapons.
It’s all different and it will take some experimentation to figure out what kind of weapon you want to use. If a boss is ghost or translucent, there’s a good chance they’re immune to poison, and you’re better off using whatever other weapons you’ve leveled up on your character.
https://www.gamepur.com/guides/can-bosses-be-poisoned-in-elden-ring-answered Can bosses be poisoned in Elden Ring? answered